When you think of HIV prevention, condoms are probably the first thing that comes to mind. This is great as condoms are a proven method to reduce your risk of contracting HIV or other STIs during sexual intercourse. However, there is another option for those who may be at a higher risk for HIV- pre-exposure prophylaxis, or PrEP. PrEP involves taking a pill once daily to prevent HIV infection in someone who is HIV-negative. Two medications are currently approved by the FDA for PrEP and both combine drugs effective against HIV that are taken in one pill:
- Truvada®: approved in 2012 for all adults and adolescents with HIV risk
- Descovy®: approved in 2019 for many adults and adolescents at risk for HIV. Due to a lack of research, Descovy is not currently approved for use in those at risk for HIV through receptive vaginal sex.
When taken consistently, every day, PrEP has been shown to reduce the risk of HIV infection in people who are at high risk by more than 90%.
So who is PrEP recommended for? The Centers for Disease Control and Prevention (CDC) offers these guidelines on people who should consider taking PrEP:
- Anyone who is in an ongoing relationship with someone who is HIV-positive.
- Gay or bisexual men who have had anal sex without a condom or have been diagnosed with an STI in the past 6 months.
- Heterosexual men or women who do not regularly use condoms with partners with an unknown HIV status who are at substantial risk for HIV infections (e.g. people who inject drugs).
- People who have injected illicit drugs in the past 6 months and have shared injection equipment or have been in treatment for injection drug use in the past 6 months.
While PrEP is recommended for different groups, it has received the most attention in the gay community. Gay and bisexual men are disproportionately affected by HIV: in 2013, they accounted for 81% estimated HIV diagnoses among all males aged 13 years and older and 65% of all persons receiving an HIV diagnosis that year. Given these alarming statistics, PrEP has been endorsed as an important prevention tool by a number of prominent activists and organizations, including the Human Rights Campaign, the Gay Men’s Health Crisis, AIDS United, and the World Health Organization.
However, PrEP has garnered some controversy as well. Among the criticisms is one that echoes the controversy that surrounds HPV vaccines—the assumption that PrEP will lead to risky sexual behavior and promote promiscuity. But as with HPV vaccination, research has shown that such fears are unfounded. A study of the multinational iPrEx study that first established the effectiveness of a daily dose of Truvada to prevent HIV found “no evidence of risk compensation that would offset the benefits of PrEP.” In other words, no evidence that taking PrEP led to risky sexual behavior. In fact, the reverse was true. As the study authors note, “Indeed, participation in the study was associated with safer sexual behavior.”
Another concern voiced is that PrEP will cause gay and bisexual men to abandon condoms, which have been a mainstay of HIV prevention efforts. But an analysis by CDC shows condom use on the declinebefore the approval of Truvada as PrEP in 2012. The CDC data indicate that in 2011, 57 percent of men who have sex with men reported having unprotected anal sex at least once in the previous 12 months, up from 48 percent in 2005. Given the decline in condom use, the availability of another prevention method should be welcomed.
But this not to suggest that PrEP replaces condoms. Far from it. Rather, PrEP offers a new option to those at high risk—another tool in the HIV prevention toolbox that fits alongside condoms, not as a replacement. After all, while PrEP helps prevent HIV infection, condoms offer protection against a host of other STIs as well.
Despite the promise offered by PrEP, it is necessarily the right choice for everyone. In addition to requiring taking a pill every day consistently, those on PrEP are also advised to see their healthcare provider regularly for follow up and get tested for HIV every 3 months. But for those willing to take on the commitment, PrEP offers the promise of a highly effective way to prevent HIV.
If you’re interested in PrEP and want to find a PrEP provider near you, check out our website sayyestoprep.org.
Learn More about PrEP
- The Advocate series “31 Days of PrEP”
- FAQs about PrEP from CDC
- Booklets from Project Inform
“Is taking PrEP the right choice for you?” (for men and transgender women who have sex with men)
“PrEP: A new option for women for safer loving” (for women who have sex with men)
- Stories from men who explain why they take PrEP from the Advocate